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Further analysis, including PCA, differential metabolite screening, and pathway enrichment analysis, was conducted using MetaboAnalyst 6.0 ( 51

The sleep onset mechanism is a little complicated Human plasma DSIP decreases at the beginning of sleep (but giving someone Delta sleep inducing peptide induces sleep) (Schoenenberger et al., 1988)

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The strongest evidence is in the CIA model, due to the greater number of studies performed

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Research shows DSIP enhances enkephalin and endorphin signaling, the body's natural pain-relieving peptides, potentially providing analgesia without the addiction liability associated with exogenous opioid medications